Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Some products that may interact with this drug include: "blood thinners" such as warfarin cyclosporine, danazol, gemfibrozil. Retrieved 15 January 2013. PLOS ONE. 8 12: e83759. esomeprazole packages esomeprazole
VYTORIN to cholestyramine may be reduced by this interaction. Therefore, red yeast might also cause side effects similar to statin drugs, such as liver damage and severe muscle pain and muscle damage. There is also concern about product quality. Many red yeast rice products have been found to contain varying amounts of the statin-like chemicals. Some products may contain none and others may contain high amounts, which are more likely to cause serious side effects. Serious allergic reactions can occur after breathing in red yeast. Red yeast that is not fermented correctly may contain citrinin. Citrinin is a poison that may cause kidney damage.
VYTORIN should be prescribed with caution in the elderly. Grapefruit juice should be avoided during simvastatin treatment. Red yeast contains the statin drug lovastatin. Lovastatin might harm the liver in some people. Taking red yeast along with other medications that might also harm the liver might increase the risk of liver damage. Do not take red yeast if you are taking another medication that can harm the liver. Sprinkle them on your salad, cereal, yogurt, fruit, vegetables, or entrees, suggest Keecha Harris, DrPh, RD and Ruth Frechman, RD, both spokeswomen for the ADA. Use nuts in pasta salads or in hot soups.
Amiodarone: May increase the serum concentration of Simvastatin. Management: Consider using a non-interacting statin pravastatin in patients on amiodarone. If combined, limit the simvastatin dose to 20 mg daily and monitor for evidence of simvastatin toxicities eg, myalgia, liver function test elevations, rhabdomyolysis. If you have known heart disease, diabetes, or multiple risk factors, you are at high risk. Most people in this group will require a combination of cholesterol-lowering drugs and lifestyle changes to control their cholesterol levels. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule.
Guo XM, Tu L Mi S. Comparison of the therapeutic effects of Zhibituo and simvastatin for regulating dyslipidemia. Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high cholesterol or triglycerides do not feel sick. Comparison of Zhibituo and simvastatin for their effects on hyperlipidemia. Lu, G. and Gong, L. The comparison of hypolipidemic effects of Xue-Zhi-Kang and simvastatin on patients with hypercholesterolemia. UpToDate: “Patient information: High cholesterol treatment options Beyond the Basics. Dasatinib: May increase the serum concentration of CYP3A4 Substrates. This medication may rarely cause liver problems. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Most people who take statin drugs tolerate them very well. But some people experience side effects. Some people with high cholesterol achieve the best results with combination drugs. These drugs treat cholesterol problems and are sometimes combined with medications like blood pressure drugs in one pill. May be administered without regard to meals. Administer in the evening for maximal efficacy. Cheng XM, Yu ZM Luo HD Qiu YH Chen MX. Effect of Xuezhikang on endothelial function in patients with hyperlipidemia. Thanks everyone who comments. These are usually the first type of drug that doctors prescribe to lower LDL. They also lower triglycerides, which are another type of blood fat, and mildly raise your "good" HDL cholesterol. Higher systemic exposure may be achieved in patients with severe renal insufficiency.
Lapi F, Gallo E, Bernasconi S, et al. Myopathies associated with red yeast rice and liquorice: spontaneous reports from the Italian Surveillance System of Natural Health Products. Asunaprevir: May increase the serum concentration of HMG-CoA Reductase Inhibitors. Retrieved 2011-06-09. The cholesterol-lowering drug simvastatin can cause severe muscle damage and should not be prescribed in high doses to patients who have taken it for less than a year or in any dose to people taking certain drugs, health officials said Tuesday. Wang YF, Yang CK Xu WJ Sun L Liu B Wang GG. Xuezhikang, gemfibrozil for regulation of hyperlipidemia in elderly and insulin sensitivity. If you miss a dose of simvastatin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Eating too much sugar and too many simple carbohydrates will also increase your cholesterol levels. Clarithromycin: May increase the serum concentration of Simvastatin. Some medications that can harm the liver include acetaminophen Tylenol and others amiodarone Cordarone carbamazepine Tegretol isoniazid INH methotrexate Rheumatrex methyldopa Aldomet fluconazole Diflucan itraconazole Sporanox erythromycin Erythrocin, Ilosone, others phenytoin Dilantin lovastatin Mevacor pravastatin Pravachol simvastatin Zocor and many others. Adverse events were not observed in animal reproduction studies. There are reports of congenital anomalies following maternal use of HMG-CoA reductase inhibitors in pregnancy; however, maternal disease, differences in specific agents used, and the low rates of exposure limit the interpretation of the available data Godfrey, 2012; Lecarpentier, 2012. Cholesterol biosynthesis may be important in fetal development; serum cholesterol and triglycerides increase normally during pregnancy. The discontinuation of lipid lowering medications temporarily during pregnancy is not expected to have significant impact on the long term outcomes of primary hypercholesterolemia treatment. ELDERLY; they may be more sensitive to its effects, especially muscle problems. Keep container tightly closed. naprosyn
Due to the increased risk of myopathy including rhabdomyolysis particularly during the first year of treatment, use of the 80 mg dose should be restricted to patients who have been taking 80 mg for 12 months or more without evidence of muscle toxicity. CoQ10 supplements on your own, however. Work with your doctor when you take any supplement. Use simvastatin as directed by your doctor. Check the label on the medicine for exact dosing instructions. Studies have shown that taking statins can lower those risks in large groups of people, but the impact on a person's individual risk is much smaller. Lots of things can affect your cholesterol levels. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider.
Zhiwei, S. A prospective study on Zhitai capsule in the treatment of primary hyperlipidemia. Palbociclib: May increase the serum concentration of CYP3A4 Substrates. Chen ZM. Comparison of the therapeutic effects of simvastatin and Zhibituo for treatment of hyperlipidemia. Zheng FS, Long XD Liu HM Liu YL Bao YZ Yu M. Comparison of lovastatin and Chinese Xuezhikang in lipid modification for primary hyperlipidemia. Lanthanum: HMG-CoA Reductase Inhibitors may decrease the serum concentration of Lanthanum. Management: Administer HMG-CoA reductase inhibitors at least two hours before or after lanthanum. Azithromycin Systemic: May enhance the myopathic rhabdomyolysis effect of Simvastatin. Becker DJ, Gordon RY, Halbert SC, et al. Red yeast rice for dyslipidemia in statin-intolerant patients: A randomized trial. Diarrhea; headache; symptoms of upper respiratory tract infection eg, mild cough or sore throat, runny or stuffy nose, sneezing. Antacids: May decrease the serum concentration of HMG-CoA Reductase Inhibitors. Li LH, Deng GL Chen YZ. CIinical comparative study of simvastatin and Xuezhikang and pravastatin in common doses on primary hyperlipidemia. Women who are pregnant or may become pregnant. Cholestin inhibits cholesterol synthesis and secretion in hepatic cells HepG2. Lowering high cholesterol and triglycerides in certain patients. It also increases high-density lipoprotein HDL "good" cholesterol levels. It is used along with an appropriate diet. It is used in certain patients to reduce the risk of heart attack, stroke, and death due to coronary heart disease. It is also used to reduce the need for medical procedures to open blocked blood vessels. It is also used in certain patients to reduce the risk of heart attack, stroke, blood vessel blockage, or chest pain caused by angina. It may also be used for other conditions as determined by your doctor. If patient is unable to achieve low-density lipoprotein-cholesterol LDL-C goal using the 40 mg dose of simvastatin, increasing to 80 mg dose is not recommended. Instead, switch patient to an alternative LDL-C-lowering treatment providing greater LDL-C reduction. Therapy should be individualized according to patient response. cheap remeron mail order pharmacy
Endo, A. Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. Lercanidipine: May increase the serum concentration of Simvastatin. Management: Administer lercanidipine in the morning and simvastatin in the evening in patients receiving these drugs in combination. Havel R. Dietary supplement or drug? Wang SH, Sun JL Liu HQ. Therapeutic observations of Xuezhikang for treatment of 60 cases of elderly with hyperlipidemia. Kritchevsky, D. Hypolipidemic and anti-atherogenic effects of long-term Cholestin Monascus purpureus-fermented rice, red yeast rice in cholesterol fed rabbits. J Nutr. Wang CW, Gao FM You L. Clinical study on the therapeutic effects of Xuezhikang for treatment of hyperlipidemia. Used as a complement to traditional, Western medicine, massage can promote relaxation and reduce or side effects of treatment. Patients requiring only moderate reduction of LDL-C: May be started at 5 to 10 mg once daily in the evening; adjust to achieve recommended LDL-C goal. MI, cardiac death, stroke, or any revascularization procedure. Take this by with or without food as directed by your doctor, usually once daily in the evening. Colchicine: May enhance the myopathic rhabdomyolysis effect of HMG-CoA Reductase Inhibitors. Colchicine may increase the serum concentration of HMG-CoA Reductase Inhibitors.
Follow the diet and exercise program given to you by your health care provider. Changling, L. Monascus purpureus-fermented rice red yeast rice: a natural food product that lowers blood cholesterol in animal models of hypercholesterolemia. Patient may experience headache, abdominal pain, nausea, constipation, cough, rhinitis, rhinorrhea, or pharyngitis. Have patient report immediately to prescriber signs of liver problems dark urine, feeling tired, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin or eyes arrhythmia, urinary retention, change in amount of urine passed, muscle pain, muscle tenderness, or muscle weakness HCAHPS. The arteries become narrowed and flow to the muscle is slowed down or blocked. Qi MY, Z J X JG. Clinical observation of Xuezhikang on treatment of 112 cases of hypercholesterolemia. Su, M. The clinical examinations of Xue-Zhi-Kang in the treatment for hypercholesterolemia. Retterstol, K. HypoCol red yeast rice lowers plasma cholesterol - a randomized placebo controlled study. Scand. Simvastatin 20 to 40 mg per day modestly potentiates the effect of warfarin anticoagulants. Li Y, Min YB Fan XJ. Comparison of the therapeutic effects of Zhibituo and fish oils for treatment of 30 cases of hyperlipidemia. Gelbach P, Li T, Hatef E 2016. May be taken without regard to meals. Red yeast rice contains variable amounts of several compounds that are structurally similar to HMG-CoA reductase inhibitors, primarily monacolin K or mevinolin which is structurally identical to lovastatin; concurrent use of red yeast rice with HMG-CoA reductase inhibitors may increase the incidence of adverse and toxic effects Lapi, 2008; Smith, 2003. Li, H. Effect of xuezhikang on alpha1- and beta2-microglobulin in patients with essential hypertension. Fibrates lower triglyceride levels and can increase HDL and lower LDL. It's thought that fibrates enhance the breakdown of triglyceride-rich particles and decrease the secretion of certain blood fats. How should I store VYTORIN? DAPTOmycin. Specifically, the risk of skeletal muscle toxicity may be increased. Management: Consider temporarily stopping HMG-CoA reductase inhibitor therapy prior to daptomycin. Wang LB, Qiao JJ Li YM. Clinical evaluation of Zhibituo and concentrated fish oils for treatment of hyperlipidemia. lopressor free
Chinese patients who are taking large amounts of niacin greater than or equal to 1 gram or 1000 milligrams per day together with simvastatin may have an increased risk for muscle injury. Li FL, Zeng WH. Comparison of Zhibituo and Inositol nicotinate for treatment of hyperlipidemia. Do NOT take more than the recommended dose without checking with your doctor. Use of simvastatin is contraindicated in pregnancy. HMG-CoA reductase inhibitors should be discontinued prior to pregnancy ADA, 2013. If treatment of dyslipidemias is needed in pregnant women or in women of reproductive age, other agents are preferred Berglund, 2012; Stone, 2013. The manufacturer recommends administration to women of childbearing potential only when conception is highly unlikely and patients have been informed of potential hazards. Warnings: Pregnancy and breast-feeding: Red yeast is LIKELY UNSAFE during pregnancy. It has caused birth defects in animals. Not enough is known about the safety of using red yeast during breast-feeding. Association. FDA web site. American Dietetic Association web site. There are several different types of prescription drugs that lower LDL. Get to know what each of them does. Store colchicine at room temperature, between 68 and 77 degrees F 20 and 25 degrees C in a tightly closed container. Store away from heat, light, and moisture. Do not store in the bathroom. Keep colchicine out of the reach of children and away from pets. If an alternate etiology is not identified, do not restart simvastatin. Liver enzyme tests should be obtained at baseline and as clinically indicated; routine periodic monitoring of liver enzymes is not necessary. Ethanol may enhance the potential of adverse hepatic effects; instruct patients to avoid excessive ethanol consumption.
Check with your doctor if you have questions. Chinese patients applies to other Asian patients. Smith, D. J. and Olive, K. E. Chinese red rice-induced myopathy. South. Red yeast contains chemicals similar to the prescription drugs called "statins. Within a few weeks of stopping the drug, he felt much better. His pain was reduced and some nagging problems also improved. However, not all cholesterol is bad. It's good, for instance, to have high levels of HDL "good" cholesterol. LDL levels tend to rise. Sarilumab: May decrease the serum concentration of CYP3A4 Substrates. Yu HY, Li TH. Observations on the therapeutic effects of Zhibituo for treatment of hyperlipidemia. redustat
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Xu SG. Analysis of therapeutic effect of Xuezhikang for treatment of primary hypercholesterolemia. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Feuerstein, J. S. and Bjerke, W. S. Powdered red yeast rice and plant stanols and sterols to lower cholesterol. Side effects: For bile acid drugs, the most common side effects are constipation, gas, and upset stomach. Email-Lab work is ordered for me-I'll have that done Monday. Eating grapefruit or drinking grapefruit juice may increase the amount of simvastatin in your blood, which may increase your risk for serious side effects. The risk may be greater with large amounts of grapefruit or grapefruit juice. Avoid large amounts of grapefruit or grapefruit juice eg, more than 1 quart daily. Talk with your doctor or pharmacist if you have questions about including grapefruit or grapefruit juice in your diet while you are taking simvastatin. Simvastatin is a substrate for CYP3A4. Educate patient about signs of a significant reaction eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions. When you take a statin, you do more than improve your cholesterol levels.
In the UK, the patent for simvastatin had expired by 2004. Red yeast is the product of rice fermented with Monascus purpureus yeast. Red yeast are different from sold in Chinese grocery stores. People use red yeast as medicine. The presence of other medical problems may affect the use of simvastatin. Huang GZ, Yang S Wu ZG. Observation on therapuetic effect of Zhibituo for treatment of hyperlipidemia. Brown, D. Lipid-lowering effects of monascus purpureus red yeast rice. Ignaszewski, A. P. The impact of dietary changes and dietary supplements on lipid profile. Gasbarrini, G. Acute hepatitis caused by a natural lipid-lowering product: when "alternative" medicine is no "alternative" at all. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. If you have muscle aches, call your doctor immediately. This could be a sign of a life-threatening condition. Are There Foods or Other Drugs I Should Avoid While Taking Cholesterol-Lowering Drugs? SNP, rs4149056, were at a five-fold or 16-fold increased risk, respectively. In 2012, the Clinical Pharmacogenetics Implementation Consortium has released guidelines regarding the use of rs4149056 genotype in guiding dosing of simvastatin and updated the guideline in 2014. Kantola T, Kivisto KT, Neuvonen PJ, et al. Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. Your body needs cholesterol for cell structure, nerve function, digestion and many other vital processes. Your body makes its own cholesterol in the liver. Fatty foods and meats also contain cholesterol, which ends up floating around in the bloodstream. Overtime, this extra cholesterol adheres to the walls of arteries, forming a rigid plaque that can restrict blood flow. Sometimes, this restriction is so drastic it can cause heart attacks and strokes, among other serious cardiovascular problems. Wang DG, Li D Nie ZY. Cost-effectiveness analysis on Xuezhikang and pravastatin treatment of hypercholesterolemia. generic vivitrol otc walgreens
Zhou ZL, Liu CH. Xuezhikang for treatment of 20 cases of hyperlipidemia. LDL-C value was 124. Reduce the risk of non-fatal and stroke. Simvastatin may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking this medication. Concomitant administration of simvastatin with amiodarone, amlodipine, or ranolazine: the dose of simvastatin should not exceed 20 mg per day. The reports about memory loss, forgetfulness, and confusion span all statin products and all age groups. The FDA says these experiences are rare but that those affected often report feeling “fuzzy” or unfocused in their thinking. Mild to moderate renal impairment: No dosage adjustment necessary; simvastatin does not undergo significant renal excretion. Side effects: The main ones are flushing, itching, tingling, and headache. That was enough to convince him to take his patient, who was suffering from muscle and joint pains, off the medication. Ticagrelor: May increase the serum concentration of Simvastatin. Some people take along with statins, or -- if their cholesterol isn't too high -- instead of them. There's good evidence that some can help with cholesterol levels. All medicines may cause side effects, but many people have no, or minor, side effects. AUC for total ezetimibe. Bianchi, A. Extracts of Monascusus purpureus beyond statins--profile of efficacy and safety of the use of extracts of Monascus purpureus. Chin J Integr. Fu G, Liu WJ Wang GT. Comparison of Zhibituo and fish oil capsules for treatment of hyperlipidemia. LDL-C and inversely with the level of HDL-C.
The risk may be greater with large amounts of grapefruit or grapefruit juice. Avoid large amounts of grapefruit or grapefruit juice eg, more than 1 quart daily. Here is information you can use to help you decide what types of massage will work best for you. Which Massage Styles Are Best? It works by reducing the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks. St John's Wort: May increase the metabolism of HMG-CoA Reductase Inhibitors. Management: Consider avoiding the concomitant administration of St Johns Wort with interacting HMG-CoA reductase inhibitors in order to avoid the potential for decreased antilipemic effects. Monitor for decreased effects during concomitant therapy. Yan HD, Guo JH Jia ST. Observations of the short-term effects of Probucol in treatment of hyperlipidemia. Zhonglin, H. Toxicity study for Monascus purpureus red yeast extract. Guymer RH, Baird PN, Varsamidis M, Busija L, Dimitrov PN, Aung KZ, Makeyeva GA, Richardson AJ, Lim L, Robman LD 2013. Hu, Z. B. Identification and chemical profiling of monacolins in red yeast rice using high-performance liquid chromatography with photodiode array detector and mass spectrometry. J Pharm Biomed. IV, and V dyslipidemias. Over time, without your even being aware, this extra accumulates inside your body and begins to do damage. dorb.info meclizine
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Who should not take VYTORIN? Retrieved 12 July 2012. Simvastatin also interacts with other drugs, including some used to treat cardiovascular problems. Zhang G, M XY C XB H X M JK W MH. Study of Xuezhikang and atorvastatin on mixed type hyperlipidemia. Wang SX. Comparison of the therapeutic effects of Xuezhikang and lovastatin.
Retrieved 8 December 2016. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using colchicine while you are pregnant. Colchicine is found in breast milk. If you are or will be breast-feeding while you use colchicine, check with your doctor. Discuss any possible risks to your baby. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Diabetes mellitus: Increases in HbA 1c and fasting blood glucose have been reported with HMG-CoA reductase inhibitors; however, the benefits of statin therapy far outweigh the risk of dysglycemia.
Do not keep outdated medicine or medicine no longer needed. Safety of red yeast rice. Statins carry warnings that memory loss, mental confusion, high blood sugar, and type 2 diabetes are possible side effects. It's important to remember that statins may also interact with other medications you take. Take simvastatin by mouth with or without food, preferably in the evening, unless directed otherwise by your doctor. Chang, M. Constituents of red yeast rice, a traditional Chinese food and medicine. J Agric.
The risk of muscle injury increases when certain other medications are taken with statins. For example, if you take a combination of a statin and a fibrate -- another cholesterol-reducing drug -- the risk of muscle damage increases greatly compared to someone who takes a statin alone. Wilke, RA; Ramsey, LB; Johnson, SG; Maxwell, WD; McLeod, HL; Voora, D; Krauss, RM; Roden, DM; Feng, Q; Cooper-Dehoff, RM; Gong, L; Klein, TE; Wadelius, M; Niemi, M; Clinical Pharmacogenomics Implementation Consortium, CPIC July 2012. Side effects can include intestinal problems, liver damage rare and muscle inflammation. High blood sugar and type 2 diabetes may also be more likely with statins, although the risk is “small” and the benefits outweigh the risks, according to the FDA.